Evaluating the temporal stability of CSF-based disease classification in
pathology confirmed AD
 
   Lead Investigator:    Justin Miller
   Institution      :    Cleveland Clinic Lou Ruvo Center for Brain Health
   E-Mail           :    millerj4@ccf.org
   Proposal ID      :    902



   Proposal Description:
   The primary aims of the proposed study are to: 1) evaluate the classification     accuracy of CSF biomarkers for differentiating pathology-confirmed cases of       Alzheimer's disease from non-AD pathology (e.g., frontotemporal dementia) 2)      evaluate the temporal stability of diagnostic classifications over time. The      secondary aim is to explore the clinical and demographic characteristics          associated with cases demonstrating temporal instability over time. Evidence of   a high degree of temporal instability (i.e., changes in diagnostic category)      will have significant implications for clinical practice, and understanding the   characteristics of those demonstrating variability over time will be              particularly important.